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KMID : 1039920130200040413
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Neonatal Medicine
2013 Volume.20 No. 4 p.413 ~ p.421
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Association of Interleukin-1α-889, β-31, β-511 Polymorphism with Risk of Bronchopulmonary Dysplasia
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Kang Jeong-Hee
Lee Jeong-jin
Cho Sung-il
Choi Yu-jin
Cho Hee-Seung
Lee Gyu-Hyung
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Abstract
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Purpose: Although improvements in neonatal care techniques have increased the survival rate of preterm infants, bronchopulmonary dysplasia (BPD) remains an important factor in neonatal mortality and morbidity. BPD is a multifactorial disease associated with genetic and clinical risk factors related to lung development and perinatal inflammation. Interleukin-1 (IL-1) is a crucial cytokine in the early stages of inflammation. In the present study, we aimed to determine the association between the IL-1 polymorphisms, clinical risk factors, and BPD in preterm infants.
Methods: The study was performed who consented infants born at less than 34 weeks’ gestation. The alleles of the 3 sites of the IL-1 gene (IL-1α-889, IL-1β-31, and IL-1β-511) were determined using Taqman®-based allelic discrimination assays. Clinical data were reviewed from the medical records.
Results: A total of 31 infants with BPD and 73 control infants were enrolled in the study. The gestational age (P=0.001) and birth weight (P=0.001) were lower in the BPD group compared to those in the control group. The incidence of respiratory distress syndrome (RDS; P=0.002), patent ductus arteriosus (P=0.01), and retinopathy of prematurity (P<0.001) was higher in the BPD group compared to that in the control group. The frequency of IL-1α-889TT was higher in the BPD group (6.5% vs. 0.0%, P=0.028) compared to that in the control group. The frequencies of IL-1α-889T, IL-1β-31T, and IL-1β-511T did not differ between the BPD and control groups. In logistic regression analysis, gestational age and RDS were found to be associated with BPD.
Conclusion: IL-1α-889, IL-1β-31, and IL-1β-511 polymorphisms are not associated with the development of BPD in preterm infants.
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KEYWORD
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Bronchopulmonary dysplasia, Polymorphism, Interleukin-1
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